Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin

UVA irradiation plays a role in premature aging of the skin through triggering oxidative stress-associated stimulation of matrix metalloproteinase-1 (MMP-1) responsible for collagen degradation, a hallmark of photoaged skin. Compounds that can activate nuclear factor E2-related factor 2 (Nrf2), a tr...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Chaiprasongsuk, Anyamanee, Lohakul, Jinaphat, Soontrapa, Kitipong, Sampattavanich, Somponnat, Akarasereenont, Pravit, Panich, Uraiwan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325073/
https://ncbi.nlm.nih.gov/pubmed/28011874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.238048
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