The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer

Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as ribonucleoprotein (RNP) guides in RNA modification(1,2). To explore their role in cancer, we compared 5,473 tumor-normal genome pairs to identify snoRNAs with frequent copy number loss. The SNORD50A-SNORD50B snoRNA locus was...

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Vydáno v:Nat Genet
Hlavní autoři: Siprashvili, Zurab, Webster, Dan E, Johnston, Danielle, Shenoy, Rajani M, Ungewickell, Alexander J, Bhaduri, Aparna, Flockhart, Ross, Zarnegar, Brian J, Che, Yonglu, Meschi, Francesca, Puglisi, Joseph D, Khavari, Paul A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324971/
https://ncbi.nlm.nih.gov/pubmed/26595770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3452
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