TrpC5 mediates acute leptin and serotonin effects via Pomc neurons

The molecular mechanisms underlying acute leptin and serotonin 2C receptor induced hypophagia remain unclear. Here we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is sufficient to decrease energy expenditure and increase f...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Gao, Yong, Yao, Ting, Deng, Zhuo, Sohn, Jong-Woo, Sun, Jia, Huang, Yiru, Kong, Xingxing, Yu, Kai-jiang, Wang, Rui-tao, Chen, Hong, Guo, Hongbo, Yan, Jianqun, Cunningham, Kathryn A., Chang, Yongsheng, Liu, Tiemin, Williams, Kevin W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324780/
https://ncbi.nlm.nih.gov/pubmed/28099839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.072
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