Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors

Gastrointestinal stromal tumors represent the most common mesenchymal tumor of the digestive tract, driven by gain‐of‐function mutations in KIT. Despite its proven benefits, half of the patients treated with imatinib show disease progression within 2 years due to secondary resistance mutations in KI...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genes Chromosomes Cancer
Autori principali: Takahashi, Tsuyoshi, Elzawahry, Asmaa, Mimaki, Sachiyo, Furukawa, Eisaku, Nakatsuka, Rie, Nakamura, Hiromi, Nishigaki, Takahiko, Serada, Satoshi, Naka, Tetsuji, Hirota, Seiichi, Shibata, Tatsuhiro, Tsuchihara, Katsuya, Nishida, Toshirou, Kato, Mamoru
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324566/
https://ncbi.nlm.nih.gov/pubmed/27997714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22438
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