Negative Regulation of DNA Repair Gene (ung) Expression by the CpxR/CpxA Two-Component System in Escherichia coli K-12 and Induction of Mutations by Increased Expression of CpxR

In Escherichia coli K-12 overexpressing CpxR, transcription of the ung gene for uracil-DNA glycosylase was repressed, ultimately leading to the induction of mutation. Gel shift, DNase I footprinting, and in vitro transcription assays all indicated negative regulation of ung transcription by phosphor...

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Autores principales: Ogasawara, Hiroshi, Teramoto, Jun, Hirao, Kiyo, Yamamoto, Kaneyoshi, Ishihama, Akira, Utsumi, Ryutaro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC532440/
https://ncbi.nlm.nih.gov/pubmed/15576781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.24.8317-8325.2004
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