High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting

OBJECTIVE: α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing i...

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Bibliografiska uppgifter
I publikationen:Mol Metab
Huvudupphovsmän: Ackermann, Amanda M., Zhang, Jia, Heller, Aryel, Briker, Anna, Kaestner, Klaus H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323890/
https://ncbi.nlm.nih.gov/pubmed/28271030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.01.003
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