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High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting
OBJECTIVE: α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing i...
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| Veröffentlicht in: | Mol Metab |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5323890/ https://ncbi.nlm.nih.gov/pubmed/28271030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.01.003 |
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