Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells

The anticancer small molecule MLN4924, a Nedd8-activating enzyme (NAE) inhibitor, triggers cell-cycle arrest, apoptosis, and senescence in cancer cells. In this study, we demonstrate that MLN4924 suppresses osteosarcoma cell proliferation by inducing G2/M cell cycle arrest and apoptosis. Our results...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Shuju, Zhang, Jiaming, Deng, Zhiyuan, Liu, Huadie, Mao, Wei, Jiang, Fang, Xia, Zanxian, Li, Jia-Da
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323217/
https://ncbi.nlm.nih.gov/pubmed/27602774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11807
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