Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia

Ikaros and Foxp1 are transcription factors that play key roles in normal lymphopoiesis and lymphoid malignancies. We describe a novel physical and functional interaction between the proteins, which requires the central zinc finger domain of Ikaros. The Ikaros-Foxp1 interaction is abolished by deleti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Bond, Jonathan, Domaschenz, Renae, Roman-Trufero, Mónica, Sabbattini, Pierangela, Ferreiros-Vidal, Isabel, Gerrard, Gareth, Asnafi, Vahid, Macintyre, Elizabeth, Merkenschlager, Matthias, Dillon, Niall
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323203/
https://ncbi.nlm.nih.gov/pubmed/27588474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11688
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