Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)

Studies have investigated biguanide-derived agents for the treatment of cancers and have reported their effects against tumorspheres (TSs). The purpose of this study was determining the effects of HL156A, a newly designed biguanide with improved pharmacokinetics, on glioblastoma TSs (GMB TSs) and as...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Choi, Junjeong, Lee, Ji-Hyun, Koh, Ilkyoo, Shim, Jin-Kyoung, Park, Junseong, Jeon, Jeong Yong, Yun, Mijin, Kim, Se Hoon, Yook, Jong In, Kim, Eui Hyun, Chang, Jong Hee, Kim, Sun Ho, Huh, Yong Min, Lee, Su Jae, Pollak, Michael, Kim, Pilnam, Kang, Seok-Gu, Cheong, Jae-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323181/
https://ncbi.nlm.nih.gov/pubmed/27582539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11595
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