Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)

Studies have investigated biguanide-derived agents for the treatment of cancers and have reported their effects against tumorspheres (TSs). The purpose of this study was determining the effects of HL156A, a newly designed biguanide with improved pharmacokinetics, on glioblastoma TSs (GMB TSs) and as...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Choi, Junjeong, Lee, Ji-Hyun, Koh, Ilkyoo, Shim, Jin-Kyoung, Park, Junseong, Jeon, Jeong Yong, Yun, Mijin, Kim, Se Hoon, Yook, Jong In, Kim, Eui Hyun, Chang, Jong Hee, Kim, Sun Ho, Huh, Yong Min, Lee, Su Jae, Pollak, Michael, Kim, Pilnam, Kang, Seok-Gu, Cheong, Jae-Ho
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323181/
https://ncbi.nlm.nih.gov/pubmed/27582539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11595
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