TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

The major high-affinity thrombin receptor, proteinase activated receptor-1 (PAR-1) is expressed at low levels by the normal epithelium but is upregulated in many types of cancer, including lung cancer. The thrombin-PAR-1 signalling axis contributes to the activation of latent TGFβ in response to tis...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Smoktunowicz, Natalia, Platé, Manuela, Stern, Alejandro Ortiz, D'Antongiovanni, Vanessa, Robinson, Eifion, Chudasama, Vijay, Caddick, Stephen, Scotton, Chris J., Jarai, Gabor, Chambers, Rachel C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323169/
https://ncbi.nlm.nih.gov/pubmed/27566553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11472
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