Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels

DR4 (Death Receptor 4) and DR5 (Death Receptor 5) are two potential targets for cancer therapy due to their ability to trigger apoptosis of cancer cells, but not normal ones, when activated by their cognate ligand TRAIL (TNF related apoptosis-inducing ligand). Therapies based on soluble recombinant...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Beyrath, Julien, Chekkat, Neila, Smulski, Cristian R., Lombardo, Caterina M., Lechner, Marie-Charlotte, Seguin, Cendrine, Decossas, Marion, Spanedda, Maria Vittoria, Frisch, Benoît, Guichard, Gilles, Fournel, Sylvie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323128/
https://ncbi.nlm.nih.gov/pubmed/27409341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10508
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