Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels

DR4 (Death Receptor 4) and DR5 (Death Receptor 5) are two potential targets for cancer therapy due to their ability to trigger apoptosis of cancer cells, but not normal ones, when activated by their cognate ligand TRAIL (TNF related apoptosis-inducing ligand). Therapies based on soluble recombinant...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Beyrath, Julien, Chekkat, Neila, Smulski, Cristian R., Lombardo, Caterina M., Lechner, Marie-Charlotte, Seguin, Cendrine, Decossas, Marion, Spanedda, Maria Vittoria, Frisch, Benoît, Guichard, Gilles, Fournel, Sylvie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323128/
https://ncbi.nlm.nih.gov/pubmed/27409341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10508
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