Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly

The activation of CD40 on B cells, macrophages, and dendritic cells by its ligand CD154 (CD40L) is essential for the development of humoral and cellular immune responses. CD40L and other TNF superfamily ligands are noncovalent homotrimers, but the form under which CD40 exists in the absence of ligan...

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Detalhes bibliográficos
Main Authors: Smulski, Cristian R., Beyrath, Julien, Decossas, Marion, Chekkat, Neila, Wolff, Philippe, Estieu-Gionnet, Karine, Guichard, Gilles, Speiser, Daniel, Schneider, Pascal, Fournel, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624471/
https://ncbi.nlm.nih.gov/pubmed/23463508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427583
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