Suppression of TGF-β pathway by pirfenidone decreases extracellular matrix deposition in ocular fibroblasts in vitro

In glaucoma surgery, fibrotic processes occur, leading to impairment of liquid outflow. Activated fibroblasts are responsible for postoperative scarring. The transforming growth factor-β (TGF-β) pathway plays a key role in fibroblast function, differentiation and proliferation. The aim of this study...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Stahnke, Thomas, Kowtharapu, Bhavani S., Stachs, Oliver, Schmitz, Klaus-Peter, Wurm, Johannes, Wree, Andreas, Guthoff, Rudolf Friedrich, Hovakimyan, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322922/
https://ncbi.nlm.nih.gov/pubmed/28231275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172592
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