Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro

To elucidate and to inhibit post-surgical fibrotic processes after trabeculectomy in glaucoma therapy, we measured gene expression in a fibrotic cell culture model, based on transforming growth factor TGF-β induction in primary human tenon fibroblasts (hTFs), and used Connectivity Map (CMap) data fo...

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Detalhes bibliográficos
Publicado no:R Soc Open Sci
Main Authors: Stahnke, Thomas, Gajda-Deryło, Beata, Jünemann, Anselm G., Stachs, Oliver, Sterenczak, Katharina A., Rejdak, Robert, Beck, Julia, Schütz, Ekkehard, Möller, Steffen, Barrantes, Israel, Warsow, Gregor, Struckmann, Stephan, Fuellen, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2020
Assuntos:
Biochemistry, Cellular and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540802/
https://ncbi.nlm.nih.gov/pubmed/33047019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.200441
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