A single transcription factor is sufficient to induce and maintain secretory cell architecture

We hypothesized that basic helix–loop–helix (bHLH) MIST1 (BHLHA15) is a “scaling factor” that universally establishes secretory morphology in cells that perform regulated secretion. Here, we show that targeted deletion of MIST1 caused dismantling of the secretory apparatus of diverse exocrine cells....

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Detalles Bibliográficos
Publicado en:Genes Dev
Autores principales: Lo, Hei-Yong G., Jin, Ramon U., Sibbel, Greg, Liu, Dengqun, Karki, Anju, Joens, Matthew S., Madison, Blair B., Zhang, Bo, Blanc, Valerie, Fitzpatrick, James A.J., Davidson, Nicholas O., Konieczny, Stephen F., Mills, Jason C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322730/
https://ncbi.nlm.nih.gov/pubmed/28174210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.285684.116
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