Global view of cognate kinase activation by the human pyruvate dehydrogenase complex

The human pyruvate dehydrogenase complex (PDC) comprises four multidomain components, E1, E3, E2 and an E3-binding protein (E3BP), the latter two forming the core as E2·E3BP sub-complex. Pyruvate flux through PDC is regulated via phosphorylation (inactivation) at E1 by four PDC kinases (PDKs), and r...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Guevara, Elena L., Yang, Luying, Birkaya, Barbara, Zhou, Jieyu, Nemeria, Natalia S., Patel, Mulchand S., Jordan, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322387/
https://ncbi.nlm.nih.gov/pubmed/28230160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42760
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