Epitope Addition and Ablation via Manipulation of a Dengue Virus Serotype 1 Infectious Clone

Despite the clinical relevance, dengue virus (DENV) research has been hampered by the absence of robust reverse genetic systems to manipulate the viral serotypes for propagation and generation of mutant viruses. In this article, we describe application of an infectious clone system for DENV serotype...

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Veröffentlicht in:mSphere
Hauptverfasser: Gallichotte, Emily N., Menachery, Vineet D., Yount, Boyd L., Widman, Douglas G., Dinnon, Kenneth H., Hartman, Steven, de Silva, Aravinda M., Baric, Ralph S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322348/
https://ncbi.nlm.nih.gov/pubmed/28251184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00380-16
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