Probing the Molecular Mechanism of Human Soluble Guanylate Cyclase Activation by NO in vitro and in vivo

Soluble guanylate cyclase (sGC) is a heme-containing metalloprotein in NO-sGC-cGMP signaling. NO binds to the heme of sGC to catalyze the synthesis of the second messenger cGMP, which plays a critical role in several physiological processes. However, the molecular mechanism for sGC to mediate the NO...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pan, Jie, Yuan, Hong, Zhang, Xiaoxue, Zhang, Huijuan, Xu, Qiming, Zhou, Yajun, Tan, Li, Nagawa, Shingo, Huang, Zhong-Xian, Tan, Xiangshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322342/
https://ncbi.nlm.nih.gov/pubmed/28230071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43112
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