A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation

Neuroserpin (NS) mediated inhibition of tissue-type plasminogen activator (tPA) is important for brain development, synapse formation and memory. Aberrations in helix F and β-sheet A movement during inhibition can directly lead to epilepsy or dementia. Conserved W154 residue in a hydrophobic patch b...

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Published in:Sci Rep
Main Authors: Ali, Mohammad Farhan, Kaushik, Abhinav, Kapil, Charu, Gupta, Dinesh, Jairajpuri, Mohamad Aman
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322333/
https://ncbi.nlm.nih.gov/pubmed/28230174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42987
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