Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits

Extensive evidence has indicated that a high rate of cholesterol biogenesis and abnormal neuronal energy metabolism play key roles in Alzheimer's disease (AD) pathogenesis. Here, for we believe the first time, we used osmotin, a plant protein homolog of mammalian adiponectin, to determine its t...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Shah, S A, Yoon, G H, Chung, S S, Abid, M N, Kim, T H, Lee, H Y, Kim, M O
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322276/
https://ncbi.nlm.nih.gov/pubmed/27001618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.23
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