A Chimera Containing CD4+ and CD8+ T-Cell Epitopes of the Leishmania donovani Nucleoside Hydrolase (NH36) Optimizes Cross-Protection against Leishmania amazonesis Infection

The Leishmania donovani nucleoside hydrolase (NH36) and NH A34480 of Leishmania amazonensis share 93% of sequence identity. In mice, the NH36 induced protection against visceral leishmaniasis is mediated by a CD4+ T cell response against its C-terminal domain (F3). Besides this CD4+ Th1 response, pr...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Immunol
Päätekijät: Alves-Silva, Marcus Vinícius, Nico, Dirlei, Morrot, Alexandre, Palatnik, Marcos, Palatnik-de-Sousa, Clarisa B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2017
Aiheet:
Immunology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322207/
https://ncbi.nlm.nih.gov/pubmed/28280494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00100
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