Nalaganje...
Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model
Fragile X syndrome (FXS), caused by the loss of functional FMRP, is a leading cause of autism. Neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, we identify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2017
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321753/ https://ncbi.nlm.nih.gov/pubmed/28218269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14359 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|