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Primary demyelination in transgenic mice expressing interferon-γ

Ever since the use of interferon-γ to treat patients with multiple sclerosis resulted in enhanced disease, the role of IFN-γ in demyelination has been under question. To address this issue directly, transgenic mice were generated that expressed the cDNA of murine IFN-γ in the central nervous system...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Horwitz, Marc S., Evans, Claire F., Mcgavern, Dorian B., Rodriguez, Moses, Oldstone, Michael B.A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321678/
https://ncbi.nlm.nih.gov/pubmed/9288735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm0997-1037
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