Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

Aggregation of hypertrophic macrophages constitutes the basis of all granulomatous diseases such as tuberculosis or sarcoidosis and is decisive for disease pathogenesis. However, macrophage-intrinsic pathways driving granuloma initiation and maintenance remain elusive. Here we show that activation o...

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Publicado no:Nat Immunol
Main Authors: Linke, Monika, Pham, Ha Thi Thanh, Katholnig, Karl, Schnöller, Thomas, Miller, Anne, Demel, Florian, Schütz, Birgit, Rosner, Margit, Kovacic, Boris, Sukhbaatar, Nyamdelger, Niederreiter, Birgit, Blüml, Stephan, Kuess, Peter, Sexl, Veronika, Müller, Mathias, Mikula, Mario, Weckwerth, Wolfram, Haschemi, Arvand, Susani, Martin, Hengstschläger, Markus, Gambello, Michael J, Weichhart, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321578/
https://ncbi.nlm.nih.gov/pubmed/28092373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3655
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