A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element

Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms. Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences. Gene repression often depends on the recruitment of P...

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Publicat a:PLoS One
Autors principals: van Arensbergen, Joris, Dussaud, Sebastien, Pardanaud-Glavieux, Corinne, García-Hurtado, Javier, Sauty, Claire, Guerci, Aline, Ferrer, Jorge, Ravassard, Philippe
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321433/
https://ncbi.nlm.nih.gov/pubmed/28225770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171508
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