Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

Multisite phosphorylation regulates many transcription factors, including the Serum Response Factor partner Elk-1. Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase ERK at multiple sites potentiates recruitment of the Mediator transcriptional coactivator c...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Mylona, Anastasia, Theillet, Francois-Xavier, Foster, Charles, Cheng, Tammy M., Miralles, Francesc, Bates, Paul A., Selenko, Philipp, Treisman, Richard
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321235/
https://ncbi.nlm.nih.gov/pubmed/27738173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad1872
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