Cushing’s Syndrome mutant PKA(L205R) exhibits altered substrate specificity

The PKA(L205R) hotspot mutation has been implicated in Cushing’s Syndrome through hyperactive gain-of-function PKA signaling, however its influence on substrate specificity has not been investigated. Here, we employ the Proteomic Peptide Library (ProPeL) approach to create high-resolution models for...

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Bibliographic Details
Published in:FEBS Lett
Main Authors: Lubner, Joshua M., Dodge-Kafka, Kimberly L., Carlson, Cathrine R., Church, George M., Chou, Michael F., Schwartz, Daniel
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321106/
https://ncbi.nlm.nih.gov/pubmed/28100013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12562
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