Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression

Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girls with heterozygous mutations in the gene encoding the methyl-CpG–binding protein MeCP2 on the X chromosome. Because restoration of MeCP2 expression in a mouse model reverses neurologic deficits in adult animals, reactiv...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Sripathy, Smitha, Leko, Vid, Adrianse, Robin L., Loe, Taylor, Foss, Eric J., Dalrymple, Emily, Lao, Uyen, Gatbonton-Schwager, Tonibelle, Carter, Kelly T., Payer, Bernhard, Paddison, Patrick J., Grady, William M., Lee, Jeannie T., Bartolomei, Marisa S., Bedalov, Antonio
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2017
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321041/
https://ncbi.nlm.nih.gov/pubmed/28143937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621356114
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