Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis

Disruption of the blood–brain barrier (BBB) is a defining and early feature of multiple sclerosis (MS) that directly damages the central nervous system (CNS), promotes immune cell infiltration, and influences clinical outcomes. There is an urgent need for new therapies to protect and restore BBB fun...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lengfeld, Justin E., Lutz, Sarah E., Smith, Julian R., Diaconu, Claudiu, Scott, Cameron, Kofman, Sigal B., Choi, Claire, Walsh, Craig M., Raine, Cedric S., Agalliu, Ilir, Agalliu, Dritan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320985/
https://ncbi.nlm.nih.gov/pubmed/28137846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609905114
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