The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma

BACKGROUND: HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. Deregulation of the Hippo pathway induces an abnormal cellular transformation,...

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Detalhes bibliográficos
Publicado no:J Otolaryngol Head Neck Surg
Main Authors: Alzahrani, Faisal, Clattenburg, Leanne, Muruganandan, Shanmugam, Bullock, Martin, MacIsaac, Kaitlyn, Wigerius, Michael, Williams, Blair A., Graham, M. Elise R., Rigby, Matthew H., Trites, Jonathan R. B., Taylor, S. Mark, Sinal, Christopher J., Fawcett, James P., Hart, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320711/
https://ncbi.nlm.nih.gov/pubmed/28222762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40463-017-0187-1
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