The Hippo component YAP localizes in the nucleus of human papilloma virus positive oropharyngeal squamous cell carcinoma

BACKGROUND: HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. Deregulation of the Hippo pathway induces an abnormal cellular transformation,...

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Pubblicato in:J Otolaryngol Head Neck Surg
Autori principali: Alzahrani, Faisal, Clattenburg, Leanne, Muruganandan, Shanmugam, Bullock, Martin, MacIsaac, Kaitlyn, Wigerius, Michael, Williams, Blair A., Graham, M. Elise R., Rigby, Matthew H., Trites, Jonathan R. B., Taylor, S. Mark, Sinal, Christopher J., Fawcett, James P., Hart, Robert D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320711/
https://ncbi.nlm.nih.gov/pubmed/28222762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40463-017-0187-1
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