Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity

Liposome (LP) encapsulation of doxorubicin (DOX) is a clinically validated method for cancer drug delivery, but its cellular uptake is actually lower than the free DOX. Therefore, we modified DOX-LP with a cationic polymer (Eudragit RL100; ER) to improve its cellular uptake and antitumor activity. T...

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Vydáno v:Sci Rep
Hlavní autoři: Wang, Wenxi, Shao, Anna, Zhang, Nan, Fang, Jinzhang, Ruan, Jennifer Jin, Ruan, Benfang Helen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320526/
https://ncbi.nlm.nih.gov/pubmed/28225062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43036
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