Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin

Hydroxychloroquine (HCQ) inhibits autophagy and therefore can sensitize some cancer cells to chemotherapy, but the high doses required limit its clinical use. Here we show that loading HCQ into liposomes (HCQ/Lip) decorated with a pH-sensitive TH-RGD targeting peptide (HCQ/Lip-TR) can concentrate HC...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Wang, Yang, Shi, Kairong, Zhang, Li, Hu, Guanlian, Wan, Jingyu, Tang, Jiajing, Yin, Sheng, Duan, Jiandong, Qin, Ming, Wang, Neng, Xie, Dandan, Gao, Xinle, Gao, Huile, Zhang, Zhirong, He, Qin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Basic Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922436/
https://ncbi.nlm.nih.gov/pubmed/27123811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1162930
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