Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction

The hypoxia inducible factor (HIF) pathway has been considered to be an attractive anti-cancer target. One strategy to inhibit HIF activity is through the disruption of the HIF-1α–p300 protein-protein interaction. We report herein the identification of an osmium(II) complex as the first metal-based...

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Publicado no:Sci Rep
Main Authors: Yang, Chao, Wang, Wanhe, Li, Guo-Dong, Zhong, Hai-Jing, Dong, Zhen-Zhen, Wong, Chun-Yuen, Kwong, Daniel W. J., Ma, Dik-Lung, Leung, Chung-Hang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320473/
https://ncbi.nlm.nih.gov/pubmed/28225008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42860
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