Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)

Background: Although dietary flavonoid intake has been associated with less weight gain, there are limited data on its impact on fat mass, and to our knowledge, the contribution of genetic factors to this relation has not previously been assessed. Objective: We examined the associations between flav...

ver descrição completa

Na minha lista:

Detalhes bibliográficos
Publicado no:	Am J Clin Nutr
Main Authors:	Jennings, Amy, MacGregor, Alex, Spector, Tim, Cassidy, Aedín
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Nutrition 2017
Assuntos:	Vitamins, Minerals, and Phytochemicals
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5320412/ https://ncbi.nlm.nih.gov/pubmed/28100511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.116.144394
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!

id	pubmed-5320412
record_format	dspace
spelling	pubmed-53204122017-04-21 Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2) Jennings, Amy MacGregor, Alex Spector, Tim Cassidy, Aedín Am J Clin Nutr Vitamins, Minerals, and Phytochemicals Background: Although dietary flavonoid intake has been associated with less weight gain, there are limited data on its impact on fat mass, and to our knowledge, the contribution of genetic factors to this relation has not previously been assessed. Objective: We examined the associations between flavonoid intakes and fat mass. Design: In a study of 2734 healthy, female twins aged 18–83 y from the TwinsUK registry, intakes of total flavonoids and 7 subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers, and proanthocyanidins) were calculated with the use of food-frequency questionnaires. Measures of dual-energy X-ray absorptiometry–derived fat mass included the limb-to-trunk fat mass ratio (FMR), fat mass index, and central fat mass index. Results: In cross-sectional multivariable analyses, higher intake of anthocyanins, flavonols, and proanthocyanidins were associated with a lower FMR with mean ± SE differences between extreme quintiles of −0.03 ± 0.02 (P-trend = 0.02), −0.03 ± 0.02 (P-trend = 0.03), and −0.05 ± 0.02 (P-trend < 0.01), respectively. These associations were not markedly changed after further adjustment for fiber and total fruit and vegetable intakes. In monozygotic, intake-discordant twin pairs, twins with higher intakes of flavan-3-ols (n = 154, P = 0.03), flavonols (n = 173, P = 0.03), and proanthocyanidins (n = 172, P < 0.01) had a significantly lower FMR than that of their co-twins with within-pair differences of 3–4%. Furthermore, in confirmatory food-based analyses, twins with higher intakes of flavonol-rich foods (onions, tea, and pears; P = 0.01) and proanthocyanidin-rich foods (apples and cocoa drinks; P = 0.04) and, in younger participants (aged <50 y) only, of anthocyanin-rich foods (berries, pears, grapes, and wine; P = 0.01) had a 3–9% lower FMR than that of their co-twins. Conclusions: These data suggest that higher habitual intake of a number of flavonoids, including anthocyanins, flavan-3-ols, flavonols, and proanthocyanidins, are associated with lower fat mass independent of shared genetic and common environmental factors. Intervention trials are needed to further examine the effect of flavonoid-rich foods on body composition. American Society for Nutrition 2017-03 2017-01-18 /pmc/articles/PMC5320412/ /pubmed/28100511 http://dx.doi.org/10.3945/ajcn.116.144394 Text en http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).
institution	US NLM
collection	PubMed Central
language	Inglês
format	Artigo
topic	Vitamins, Minerals, and Phytochemicals
spellingShingle	Vitamins, Minerals, and Phytochemicals Jennings, Amy MacGregor, Alex Spector, Tim Cassidy, Aedín Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
description	Background: Although dietary flavonoid intake has been associated with less weight gain, there are limited data on its impact on fat mass, and to our knowledge, the contribution of genetic factors to this relation has not previously been assessed. Objective: We examined the associations between flavonoid intakes and fat mass. Design: In a study of 2734 healthy, female twins aged 18–83 y from the TwinsUK registry, intakes of total flavonoids and 7 subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, polymers, and proanthocyanidins) were calculated with the use of food-frequency questionnaires. Measures of dual-energy X-ray absorptiometry–derived fat mass included the limb-to-trunk fat mass ratio (FMR), fat mass index, and central fat mass index. Results: In cross-sectional multivariable analyses, higher intake of anthocyanins, flavonols, and proanthocyanidins were associated with a lower FMR with mean ± SE differences between extreme quintiles of −0.03 ± 0.02 (P-trend = 0.02), −0.03 ± 0.02 (P-trend = 0.03), and −0.05 ± 0.02 (P-trend < 0.01), respectively. These associations were not markedly changed after further adjustment for fiber and total fruit and vegetable intakes. In monozygotic, intake-discordant twin pairs, twins with higher intakes of flavan-3-ols (n = 154, P = 0.03), flavonols (n = 173, P = 0.03), and proanthocyanidins (n = 172, P < 0.01) had a significantly lower FMR than that of their co-twins with within-pair differences of 3–4%. Furthermore, in confirmatory food-based analyses, twins with higher intakes of flavonol-rich foods (onions, tea, and pears; P = 0.01) and proanthocyanidin-rich foods (apples and cocoa drinks; P = 0.04) and, in younger participants (aged <50 y) only, of anthocyanin-rich foods (berries, pears, grapes, and wine; P = 0.01) had a 3–9% lower FMR than that of their co-twins. Conclusions: These data suggest that higher habitual intake of a number of flavonoids, including anthocyanins, flavan-3-ols, flavonols, and proanthocyanidins, are associated with lower fat mass independent of shared genetic and common environmental factors. Intervention trials are needed to further examine the effect of flavonoid-rich foods on body composition.
author	Jennings, Amy MacGregor, Alex Spector, Tim Cassidy, Aedín
author_facet	Jennings, Amy MacGregor, Alex Spector, Tim Cassidy, Aedín
author_sort	Jennings, Amy
title	Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
title_short	Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
title_full	Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
title_fullStr	Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
title_full_unstemmed	Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
title_sort	higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)
publisher	American Society for Nutrition
container_title	Am J Clin Nutr
publishDate	2017
url	https://ncbi.nlm.nih.gov/pmc/articles/PMC5320412/ https://ncbi.nlm.nih.gov/pubmed/28100511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.116.144394
_version_	1818870952010711040

Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins(1)(2)

Registos relacionados