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A Ddc2-Rad53 Fusion Protein Can Bypass the Requirements for RAD9 and MRC1 in Rad53 Activation

Activation of Rad53p by DNA damage plays an essential role in DNA damage checkpoint pathways. Rad53p activation requires coupling of Rad53p to Mec1p through a “mediator” protein, Rad9p or Mrc1p. We sought to determine whether the mediator requirement could be circumvented by making fusion proteins b...

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Autors principals: Lee, Soo-Jung, Duong, Jimmy K., Stern, David F.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC532024/
https://ncbi.nlm.nih.gov/pubmed/15456903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-07-0608
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