RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation.

In budding yeast, RAD9 and RAD24/RAD17/MEC3 are believed to function upstream of MEC1 and RAD53 in signalling the presence of DNA damage. Deletion of any one of these genes reduces the normal G1/S and G2/M checkpoint delays after UV irradiation, whereas in rad9Delta-rad24Delta cells the G1/S checkpo...

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Bibliographic Details
Main Authors: de la Torre-Ruiz, M A, Green, C M, Lowndes, N F
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170609/
https://ncbi.nlm.nih.gov/pubmed/9564050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.9.2687
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