A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes

There remains an urgent need for a prophylactic HIV vaccine. We compared combined MVA and adjuvanted gp140 to sequential MVA/gp140 after DNA priming. We expected Env-specific CD4+ T-cells after DNA and MVA priming, and Env-binding antibodies in 100% individuals after boosting with gp140 and that com...

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Udgivet i:Front Immunol
Main Authors: Joseph, Sarah, Quinn, Killian, Greenwood, Aldona, Cope, Alethea V., McKay, Paul F., Hayes, Peter J., Kopycinski, Jakub T., Gilmour, Jill, Miller, Aleisha N., Geldmacher, Christof, Nadai, Yuka, Ahmed, Mohamed I. M., Montefiori, David C., Dally, Len, Bouliotis, George, Lewis, David J. M., Tatoud, Roger, Wagner, Ralf, Esteban, Mariano, Shattock, Robin J., McCormack, Sheena, Weber, Jonathan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319954/
https://ncbi.nlm.nih.gov/pubmed/28275375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00149
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