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Glucopyranosyl Lipid A Adjuvant Significantly Enhances HIV Specific T and B Cell Responses Elicited by a DNA-MVA-Protein Vaccine Regimen

Using a unique vaccine antigen matched and single HIV Clade C approach we have assessed the immunogenicity of a DNA-poxvirus-protein strategy in mice and rabbits, administering MVA and protein immunizations either sequentially or simultaneously and in the presence of a novel TLR4 adjuvant, GLA-AF. M...

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Hlavní autoři:	McKay, Paul F., Cope, Alethea V., Mann, Jamie F. S., Joseph, Sarah, Esteban, Mariano, Tatoud, Roger, Carter, Darrick, Reed, Steven G., Weber, Jonathan, Shattock, Robin J.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science 2014
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3900398/ https://ncbi.nlm.nih.gov/pubmed/24465426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084707
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Glucopyranosyl Lipid A Adjuvant Significantly Enhances HIV Specific T and B Cell Responses Elicited by a DNA-MVA-Protein Vaccine Regimen

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