Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

Matrix metalloproteinase-9 (MMP-9) is robustly elevated in the first week post-myocardial infarction (MI). Targeted deletion of the MMP-9 gene attenuates cardiac remodeling post-MI by reducing macrophage infiltration and collagen accumulation through increased apoptosis and reduced inflammation. In...

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Gepubliceerd in:J Mol Cell Cardiol
Hoofdauteurs: Iyer, Rugmani Padmanabhan, de Castro Brás, Lisandra E., Patterson, Nicolle L., Bhowmick, Manishabrata, Flynn, Elizabeth R., Asher, Majdouline, Cannon, Presley L., Deleon-Pennell, Kristine Y., Fields, Gregg B., Lindsey, Merry L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319826/
https://ncbi.nlm.nih.gov/pubmed/27746126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.10.005
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