Early Matrix Metalloproteinase-12 Inhibition Worsens Post-Myocardial Infarction Cardiac Dysfunction by Delaying Inflammation Resolution

RATIONALE: Matrix metalloproteinases (MMPs) regulate remodeling of the left ventricle (LV) post-myocardial infarction (MI). MMP-12 has potent macrophage-dependent remodeling properties in the atherosclerotic plaque; however, post-MI roles have not been examined. OBJECTIVE: The goal was to determine...

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Publicat a:Int J Cardiol
Autors principals: Iyer, Rugmani Padmanabhan, Patterson, Nicolle L., Zouein, Fouad A., Ma, Yonggang, Dive, Vincent, de Castro Brás, Lisandra E., Lindsey, Merry L.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406852/
https://ncbi.nlm.nih.gov/pubmed/25797678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2015.03.054
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