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Enantioselective synthesis of an ophiobolin sesterterpene via a programmed radical cascade

Cyclase enzymes weave simple polyprenyl chains into the elaborate polycyclic ring systems of terpenes, a sequence that is often difficult to emulate under abiotic conditions. Herein we report a disparate synthetic approach to complex terpenes whereby simple prenyl-derived chains are cyclized using r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Brill, Zachary G., Grover, Huck K., Maimone, Thomas J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319821/
https://ncbi.nlm.nih.gov/pubmed/27230373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf6742
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