Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaques

Our central hypothesis is that protection against HIV infection will be powerfully influenced by the magnitude and quality of the B cell response. Although sterilizing immunity, mediated by pre-formed abundant and potent antibodies is the ultimate goal for B cell-targeted HIV vaccine strategies, sce...

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Publicado en:PLoS One
Main Authors: Jaworski, Juan Pablo, Bryk, Peter, Brower, Zachary, Zheng, Bo, Hessell, Ann J., Rosenberg, Alexander F., Wu, Tong Tong, Sanz, Ignacio, Keefer, Michael C., Haigwood, Nancy L., Kobie, James J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319772/
https://ncbi.nlm.nih.gov/pubmed/28222180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172524
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