NEURON-SPECIFIC SUMO KNOCKDOWN SUPPRESSES GLOBAL GENE EXPRESSION RESPONSE AND WORSENS FUNCTIONAL OUTCOME AFTER TRANSIENT FOREBRAIN ISCHEMIA IN MICE

Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic neurons, a neuroprotective response to ischemia....

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Vydáno v:Neuroscience
Hlavní autoři: ZHANG, LIN, LIU, XIAOZHI, SHENG, HUAXIN, LIU, SHUAI, LI, YING, ZHAO, JULIA Q., WARNER, DAVID S., PASCHEN, WULF, YANG, WEI
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319602/
https://ncbi.nlm.nih.gov/pubmed/27919694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2016.11.036
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