NEURON-SPECIFIC SUMO KNOCKDOWN SUPPRESSES GLOBAL GENE EXPRESSION RESPONSE AND WORSENS FUNCTIONAL OUTCOME AFTER TRANSIENT FOREBRAIN ISCHEMIA IN MICE

Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic neurons, a neuroprotective response to ischemia....

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Publicado no:Neuroscience
Main Authors: ZHANG, LIN, LIU, XIAOZHI, SHENG, HUAXIN, LIU, SHUAI, LI, YING, ZHAO, JULIA Q., WARNER, DAVID S., PASCHEN, WULF, YANG, WEI
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319602/
https://ncbi.nlm.nih.gov/pubmed/27919694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2016.11.036
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