Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis

Intraluminal thrombus is a consistent feature of human abdominal aortic aneurysm (AAA). Coagulation factor Xa (FXa) catalyses FII to thrombin (FIIa). We examined the effect of FXa/FIIa inhibition on experimental aortic aneurysm in apolipoprotein E-deficient (ApoE(−/−)) mice infused with angiotensin...

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Published in:Sci Rep
Main Authors: Moran, Corey S., Seto, Sai-Wang, Krishna, Smriti M., Sharma, Surabhi, Jose, Roby J., Biros, Erik, Wang, Yutang, Morton, Susan K., Golledge, Jonathan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318894/
https://ncbi.nlm.nih.gov/pubmed/28220880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43079
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