FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53

Tumour suppressor p53 or proto-oncogene MYC is frequently altered in squamous carcinomas, but this is insufficient to drive carcinogenesis. We have shown that overactivation of MYC or loss of p53 via DNA damage triggers an anti-oncogenic differentiation-mitosis checkpoint in human epidermal keratino...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Molinuevo, R, Freije, A, de Pedro, I, Stoll, S W, Elder, J T, Gandarillas, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318665/
https://ncbi.nlm.nih.gov/pubmed/27452522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.262
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