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Electrophilic modification of PKM2 by 4-hydroxynonenal and 4-oxononenal results in protein cross-linking and kinase inhibition
Rapidly proliferating cells require increased metabolism to allow for the production of nucleic acids, amino acids, and lipids. Pyruvate kinase catalyzes the final step in the glycolysis pathway and different isoforms display vastly different catalytic efficiencies. The M2 isoform of pyruvate kinase...
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| Veröffentlicht in: | Chem Res Toxicol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5318235/ https://ncbi.nlm.nih.gov/pubmed/27978618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00374 |
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