Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold. The signals controlling differential translation are poorly understood. Our...

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Publicat a:eLife
Autors principals: Burkhardt, David H, Rouskin, Silvi, Zhang, Yan, Li, Gene-Wei, Weissman, Jonathan S, Gross, Carol A
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Computational and Systems Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318159/
https://ncbi.nlm.nih.gov/pubmed/28139975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22037
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