An in vivo mechanism for the reduced peripheral neurotoxicity of NK105: a paclitaxel-incorporating polymeric micellar nanoparticle formulation

In our previous rodent studies, the paclitaxel (PTX)-incorporating polymeric micellar nanoparticle formulation NK105 had showed significantly stronger antitumor effects and reduced peripheral neurotoxicity than PTX dissolved in Cremophor(®) EL and ethanol (PTX/CRE). Thus, to elucidate the mechanisms...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Nakamura, Iwao, Ichimura, Eiji, Goda, Rika, Hayashi, Hitomi, Mashiba, Hiroko, Nagai, Daichi, Yokoyama, Hirofumi, Onda, Takeshi, Masuda, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317268/
https://ncbi.nlm.nih.gov/pubmed/28243090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S114356
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